Work

Cranial neural crest cells on the move: Their roles in craniofacial development

Year: 2010

Type: review

Abstract: The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three-dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs). In this review we discuss the newest scientific findings in the development of the craniofacial complex as related to NCCs. Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders.

Source: American Journal of Medical Genetics Part A

DOI: 10.1002/ajmg.a.33702

Authors: Dwight R. Cordero, Samantha Brugmann, Yvonne Chu, Ruchi Bajpai, Maryam Jame, Jill A. Helms

Institutions: Brigham and Women's Hospital, Harvard University, Stanford Medicine, Stanford University

Language: English

Topic: Craniofacial Disorders and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Dental and Craniofacial Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Core Research for Evolutional Science and Technology