Year: 1984
Type: article
Study design: Case Report
Abstract: THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS)has been associated with alterations in cell-mediated immunity and with a variety of infections, including ones caused by fungi.' Coccidioides immitis infection occurs frequently in endemic areas, but usually causes asymptomatic or self-limited disease.Manifestations of disseminated disease occur in about 1% of those in- fected.At risk of disseminated disease developing are persons with underlying disorders of cell-mediated im- munity, such as those suffering from reticuloendothelial malignancy and recipients of renal transplants.Preg- nant women and members of certain ethnic groups -including blacks and Filipinos are also at risk.Occasionally, disseminated coccidioidomycosis will develop in those without apparent risk factors.2Alterations in cell-mediated immunity have been found in persons with disseminated disease due to C immitis.These include impaired cutaneous hypersensitivity responses to coccidioidin and dinitrochlorobenzene and depressed in vitro lymphocyte transformation and lymphokine production.These latter phenomena may result from increased T-cell suppressor activity.Coccidioidomycosis has not previously been reported in patients with AIDS, but might be expected to dis- seminate in those infected because of the important role cell-mediated immunity plays in host defenses against coccidioidomycosis.We describe the case of a homo- sexual man with pulmonary coccidioidomycosis whose disease disseminated after AIDS had developed. Report of a CaseA 30-year-old Hispanic homosexual man, a farm worker from the San Joaquin Valley, was admitted to (Kovacs A, Forthal DN, Kovacs JA, et al: Disseminated coc- cidioidomycosis in a patient with acquired immune deficiency syndrome.
Source: PubMed Central
Authors: A Kovacs, D N Forthal, J A Kovacs, G D Overturf
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W200133880