Effect ofCYP2B6,ABCB1, andCYP3A5Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study
Year: 2010
Type: article
Abstract: In AIDS Clinical Trials Group protocols 384, A5095, and A5097s, we characterized relationships between 22 polymorphisms in CYP2B6, ABCB1, and CYP3A5; plasma efavirenz exposure; and/or treatment responses. A stepwise logistic regression procedure selected polymorphisms associated with reduced drug clearance adjusted for body mass index and the composite CYP2B6 516/983 genotype. Relationships between selected polymorphisms and treatment responses were characterized by competing risk methodology. Association analyses involved 821 individuals (317 for pharmacokinetics and 643 for treatment response). Models that included CYP2B6 516/983 genotype best predicted pharmacokinetics. Slow-metabolizer genotypes were associated with increased central nervous system events among white participants and decreased virologic failure among black participants.
DOI: 10.1086/655470
Institutions: Harvard University, Universitätsklinikum Tübingen, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, North Carolina State University, Vanderbilt University, University of Alabama at Birmingham, University at Buffalo, State University of New York, Cornell University, Weill Cornell Medicine, Washington University in St. Louis
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
Awards: G1033683653, G1050281965, Units for HIV/AIDS Clinical Trials Networks, G1068660208, G1118287939, G115468880, G1158968046, G1169301292, G119332616, G1225594167, G123932167, G127535873, G1276011396, G1290643946, G1346130624, G1380633192, G1432718094, G1479152345, G1507718124, Stanford AIDS Clinical Trials Unit, G1534260048, G1586133245, G1593133010, G161582775, WASHINGTON UNIVERSITY AIDS CLINICAL TRIALS UNIT, G16708505, G1678638035, G1681955143, G174905615, G1805005405, G185513119, Vanderbilt HIV Clinical Trials Unit, G1865158448, G193111053, G1939689254, G1944963898, G1978423557, G2027736814, G2069435444, G2093356446, G2135258891, G2199452652, G2239548760, G2241242742, G2268686290, G229144670, G232810045, G2368841045, G2370685347, G2381598486, G2394140265, G2423265107, G2501702145, G2507544392, G2539633428, G2682253789, G2703310063, G2737559749, G2833553957, General Clinical Research Center, G2916982757, ADULT AIDS CLINICAL TRIALS UNIT, G3116536149, Cornell Clinical Trials Unit, G3142995538, G3277483280, G3290139526, Johns Hopkins AIDS Clinical Trials Unit, G3406742890, G3441327761, G3483687112, G3525517067, G3667695504, G3672534956, G367367271, G374818150, G3788978964, UW Clinical HIV Integrated Research Program, G3873853564, G390975780, G3922356, G3935416247, Philadelphia IMPAACT Clinical Trials Unit, G4099673573, Vanderbilt Meharry Center for AIDS Research, G4205250407, G4316068824, G4553935269, G4649361189, Case Clinical Trials Unit, University of Pittsburgh Clinical Trials Unit, G5031627105, G5046654427, ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM IN AIDS, Integrated University of Puerto Rico Clinical Trials Unit, G5268332287, ADULT ACTG CENTRAL GROUP, G5469398932, G5588634031, G5647179126, UCSD Department of Medicine HIV/AIDS Clinical Trials Unit, The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2, Case AIDS Clinical Trials Unit, G6103943158, Philadelphia IMPAACT Clinical Trials Unit, G6186512954, G650174051, G6615853387, The Vanderbilt Institute for Clinical and Translational Research (VICTR) UL1, G6643580741, University of Cincinnati AIDS Clinical Trials Unit- UC ACTU, G6687940712, G6785868222, UCSF HIV Clinical Trials Unit, Partners Healthcare Systems/Harvard Medical School/Boston Medical Center AIDS CTU, G7348756, G749807406, G7807354757, G8487837538, HIV/AIDS Clinical Trials Unit, G857487509, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), Columbia Collaborative HIV/AIDS Clinical Trials Unit, University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit, G926868656, G936311976, G949362299, G961682679, Bridging the Gap HIV Trials and Clinical Practice
OpenAlex ID: W2001435229