Work

Exploratory methods for checking quality of microarray data

Year: 2007

Type: article

Abstract: In microarray experiments many undesirable systematic variations are commonly observed. Often investigators analyzing microarray data need to make subjective decisions about the quality of the experiment, by examining its chip image and a simple scatter plot. Thus, a more rigorous but simple method is desirable to determine the quality of microarray data. We propose two exploratory methods to investigate the quality of microarray experiments with replicated chips. The first method is based on correlations among chips and the second on the actual intensity values for each gene. The proposed methods are illustrated using a real microarray data set. The methods provide an initial estimation for determining the quality of microarray experiments.

Source: Bioinformation

DOI: 10.6026/97320630001423

Authors: Eun-Kyung Lee, Taesung Park

Institution: Seoul National University

Language: English

Topic: Gene expression and cancer classification

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: Korea Science and Engineering Foundation

OpenAlex ID: W2001439983