Work

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

Year: 1971

Type: article

Abstract: Infection of HeLa cells with poliovirus results in an inhibition of host-cell protein synthesis. Cytoplasmic extracts from infected cells contian an activity that inhibits initiation of protein synthesis in vitro by rabbit reticulocyte lysates. This inhibitory activity has been purified and characterized, and is shown to reside in poliovirus double-stranded RNA. The intact double-stranded molecule is not essential for inhibitory activity.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.68.5.1075

Authors: E. Ehrenfeld, Tim Hunt

Institution: Albert Einstein College of Medicine

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2001580461

FWCI: 5.66

Cites: 11

Cited by: 203

Related to: 10