Work

Intestinal lipid–derived signals that sense dietary fat

Year: 2015

Type: article

Abstract: Fat is a vital macronutrient, and its intake is closely monitored by an array of molecular sensors distributed throughout the alimentary canal. In the mouth, dietary fat constituents such as mono- and diunsaturated fatty acids give rise to taste signals that stimulate food intake, in part by enhancing the production of lipid-derived endocannabinoid messengers in the gut. As fat-containing chyme enters the small intestine, it causes the formation of anorexic lipid mediators, such as oleoylethanolamide, which promote satiety. These anatomically and functionally distinct responses may contribute to the homeostatic control and, possibly, the pathological dysregulation of food intake.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci76302

Authors: Nicholas V. DiPatrizio, Daniele Piomelli

Institutions: University of California, Irvine, Italian Institute of Technology

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases