Quantitative bioluminescence tomography guided by diffuse optical tomography
Year: 2008
Type: article
Abstract: We present for the first time experimental evidence that the quantitative accuracy of bioluminescence tomography (BLT) can be significantly improved by incorporating prior spatial distribution of optical properties of heterogeneous media obtained from diffuse optical tomography (DOT). A series of experiments were conducted using a CCD-based scanning system where millimeter-size bioluminescent targets were embedded in a 3 x 3 x 5 cm optically heterogeneous scattering medium. The results show that the BLT images with the recovered optical property distribution in place are considerably better reconstructed compared to that without such prior information, in terms of the location, size and source strength of the targets.
Source: Optics Express
DOI: 10.1364/oe.16.001481
Authors: Qizhi Zhang, Lu Yin, Yiyong Tan, Zhen Yuan, Huabei Jiang
Institution: University of Florida
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,270
OpenAlex ID: W2001765614