Work

An alternative explanation for a postulated non-thermal, non-cavitational ultrasound mechanism of action on in vitro cells at hyperthermic temperature

Year: 1990

Type: article

Abstract: V-79 cells were suspended in medium with 10 or 20% serum, and exposed to a continuous wave of 1 or 3.4 MHz ultrasound (0.7–1 W/cm2) for 0–90 min in polystyrene test tubes at 37 or 43°C, and subsequently assessed for cell lysis, plating efficiency and surviving fraction. The effectiveness of the ultrasound regimens was enhanced at 43°C. Thermocouple measurements of temperatures in the cell culture medium in the test-tube revealed an increase of about 0.5°C under insonation conditions, using the 1 MHz; 10% serum; 37°C regimen. The results were broadly consistent with an ultrasound-induced incremental theraml burden causing an increased effectiveness of the ultrasound exposures at hyperthermic temperatures.

Source: Ultrasonics

DOI: 10.1016/0041-624x(90)90084-2

Authors: M. Inoue, Charles C. Church, Morton W. Miller

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,680