Work

Calculation of the biological effective dose for piecewise defined dose‐rate fits

Year: 2009

Type: article

Abstract: An algorithmic solution to the biological effective dose (BED) calculation from the Lea-Catcheside formula for a piecewise defined function is presented. Data from patients treated for metastatic thyroid cancer were used to illustrate the solution. The Lea-Catcheside formula for the G-factor of the BED is integrated numerically using a large number of small trapezoidal fits to each integral. The algorithmically calculated BED is compatible with an analytic calculation for a similarly valued exponentially fitted dose-rate plot and is the only resolution for piecewise defined dose-rate functions.

Source: Medical Physics

DOI: 10.1118/1.3070587

Authors: Robert F. Hobbs, George Sgouros

Institution: Johns Hopkins University

Language: English

Topic: Advanced Radiotherapy Techniques

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Universität Duisburg-Essen, National Cancer Institute