Year: 2015
Type: review
Abstract: Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.
Source: Emerging infectious diseases
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
Awards: Social, Economic and Environmental Drivers of Zoonoses in Tanzania (SEEDZ), Hazards Associated with Zoonotic enteric pathogens in Emerging Livestock meat pathways (HAZEL), G1886633764, G3028693477, G3168060087, G3204045353, The impact and social ecology of bacterial zoonoses in northern Tanzania, G4518260094, G5156098791, The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: Under, G5443035086, Molecular epidemiology of brucellosis in northern Tanzania, G7855057906, G8383793600
OpenAlex ID: W2002033125