Work

Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non-α7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons

Year: 2012

Type: article

Abstract: Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.0115-12.2012

Authors: Sergio Arroyo, Corbett Bennett, David Aziz, Solange P. Brown, Shaul Hestrin

Institutions: University of Arizona, Stanford Medicine, Stanford University, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Nicotinic Acetylcholine Receptors Study

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: National Eye Institute

Award: G2154912420