Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China
Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies. METHODS: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China. RESULTS: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2). CONCLUSION: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.
Source: BMC Cancer
Institutions: National Institutes of Health, Division of Cancer Epidemiology and Genetics, Shanghai Cancer Institute, The University of Texas MD Anderson Cancer Center, Fudan University, Zhongshan Hospital, Ruijin Hospital, Second Military Medical University, Westat (United States), National Cancer Institute
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,390
OpenAlex ID: W2002281127