Year: 1979
Type: article
Abstract: The development of juvenile onset diabetes in man has been associated with several viral infections, including mumps, rubella and coxsackie virus [4, 6, 171. Pancreatitis with or without insulitis also has occurred with mumps, rubella and coxsackie virus infections. Reports of generalized cytomegalovirus infections of infants with morphologic signs of infection in several organs, including the pancreas, are not infrequent. Pancreatitis and insulitis sometimes occur with characteristic nuclear and cytoplasmic inclusion bodies in islet cells and acinar and ductal epithelial cells. Generalized cytomegalovirus infections also have been associated with immunodeficient patients and the pancreatic involvement has been similar to that reported in neonates [8, 13, 19). The most persuasive evidence for virus induced diabetes, however, has been the production of diabetes in mice by both reo-3 and encephalomyocarditis virus 12, IS]. Characteristic inclusions also have been found in islet beta cells in immunosuppressed mice infected with cytomegalovirus [I]. We recently reported diabetes mellitus in degus (Ocrodon degu) [5, LO, 141. We now report characteristic cytomegalovirus inclusion bodies in islet cells (fig. 1) and acinar (fig. 2) and
Source: Veterinary Pathology
Authors: J. G. Fox, J. C. Murphy
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W2002492451