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Patterns of Acute Rhesus Cytomegalovirus (RhCMV) Infection Predict Long-Term RhCMV Infection

Year: 2012
Type: article
Abstract: We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.
DOI: 10.1128/jvi.00607-12
Authors: Basel T. Assaf, Keith G. Mansfield, Susan V. Westmoreland, Amitinder Kaur, Kristie L. Oxford, Don J. Diamond, Peter A. Barry
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: bronze
Awards: G1289458277, G1737803372, G258100121, G273869597, G401230023, G4495922382, Research Training in Veterinary & Comparative Pathology, MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATION, G9000004645
OpenAlex ID: W2002725288
FWCI: 1.722
Cites: 23
Cited by: 18
Related to: 10