Work

Genomic Technology Applied to Pharmacological Traits

Year: 2011

Type: article

Abstract: Advances in genomic technologies have enabled a deeper understanding of a variety of phenotypes relevant to clinical medicine. The ability to test hundreds of thousands of inherited genetic markers for association with medical traits (genome-wide association studies, or GWAS) has led to exciting new discoveries. While GWAS of diseases focuses on disease onset and rate of progression, the term pharmacogenomics refers to the application of GWAS and related genomic technologies to understanding variability in treatment outcome of a disease (a drug's efficacy or toxicity).

Source: JAMA

DOI: 10.1001/jama.2011.1125

Authors: Jun J. Yang, Robert M. Plenge

Institutions: St. Jude Children's Research Hospital, Brigham and Women's Hospital

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases