Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
Year: 2015
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. METHODS: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. RESULTS: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR=0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; Ptrend=0.029. While there was no significant effect modification by hormone receptor status (P=0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P=0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR=0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (Ptrend=0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR=0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. CONCLUSIONS: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.
Source: Breast Cancer Research
Authors: Nirmala Bhoo-Pathy, Petra HM Peeters, Cuno SPM Uiterwaal, H Bas Bueno-de-Mesquita, Awang M Bulgiba, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Anja Olsen, Françoise Clavel-Chapelon, Guy Fagherazzi, Florence Perquier, Birgit Teucher, Rudolf Kaaks, Madlen Schütze, Heiner Boeing, Pagona Lagiou, Philippos Orfanos, Antonia Trichopoulou, Claudia Agnoli, Amalia Mattiello, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Franzel JB van Duijnhoven, Tonje Braaten, Eiliv Lund, Guri Skeie, María-Luisa Redondo, Genevieve Buckland, Maria José Sánchez Pérez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Elisabet Wirfält, Peter Wallström, Ingegerd Johansson, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Timothy J Key, Sabina Rinaldi, Isabelle Romieu, Valentina Gallo, Elio Riboli, Carla H van Gils
Institutions: Ministry of Health, Hospital Kuala Lumpur, University Medical Center Utrecht, University of Malaya, Imperial College London, National Institute for Public Health and the Environment, Aarhus University, Danish Cancer Society, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, German Cancer Research Center, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, Istituto per lo Studio e la Prevenzione Oncologica, Italian institute for Genomic Medicine, Piedmont Reference Center for Epidemiology and Cancer Prevention, Wageningen University & Research, UiT The Arctic University of Norway, Gobierno del Principado de Asturias, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Instituto de Salud Pública de Navarra, Lund University, Umeå University, University of Cambridge, MRC Epidemiology Unit, Medical Research Council, University of Oxford, Centre international de recherche sur le cancer, Queen Mary University of London
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Ministry of Higher Education, Malaysia, Lunds Universitet, Ligue Contre le Cancer, NordForsk, Associazione Italiana per la Ricerca sul Cancro, National and Kapodistrian University of Athens, Deutsche Krebshilfe, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Asialink, University of Melbourne, Instituto de Salud Carlos III, Medicinska Fakulteten, Lunds Universitet
OpenAlex ID: W2002752091