Work

The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

Year: 2011

Type: article

Abstract: The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

Source: Organic Letters

DOI: 10.1021/ol102915f

Authors: Armando R. Hernández, Eric T. Kool

Institution: Stanford University

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G4649138597, G4839374287, Probing the Steric Restrictions of RISC using xRNA-Containing siRNAs, RE-ENGINEERING THE DIAMETER OF THE DOULBE HELIX