Work

In VitroModeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia

Year: 2013

Type: article

Abstract: Human bocavirus 1 (HBoV1) is an emerging human-pathogenic respiratory virus. We characterized two important features of HBoV1 infection in polarized primary human airway epithelia (HAE). Apical HBoV1 infection of HAE at a low multiplicity of infection causes disruption of the tight junction barrier, loss of cilia, and epithelial cell hypertrophy, which are hallmarks of the airway epithelial damage caused by HBoV1 infection. HBoV1 also infects HAE from the basolateral surface productively, although less efficiently, and this also leads to the characteristic airway epithelial damage.

Source: Journal of Virology

DOI: 10.1128/jvi.03132-12

Authors: Xuefeng Deng, Ziying Yan, Yong Luo, Jian Xu, Fang Cheng, Yi Li, John F. Engelhardt, Jianming Qiu

Institutions: Central China Normal University, University of Kansas Medical Center, University of Iowa, Zhejiang Chinese Medical University

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences

Awards: G1249904872, G1328276267, G3005125101, G3185723841, G336615015, G3507472349, G4479693046, G6297116679, Environmental Health Sciences Research Center, Precision Medicine Center for Cystic Fibrosis

OpenAlex ID: W2002830034

FWCI: 4.753

Cites: 35

Cited by: 60

Related to: 10