Pleiotrophin Regulates Normal and Leukemic Hematopoietic Stem Cell Fate
Year: 2012
Type: article
Abstract: We recently demonstrated the cytokine pleiotrophin (PTN) is a growth factor for hematopoietic stem cells (HSCs) in vitro and systemic administration of PTN is sufficient to accelerate HSC regeneration following injury in vivo (Himburg, Nat Med 2010). To determine whether PTN signaling is necessary for maintenance of the HSC pool in vivo, we characterized the HSC content of mice bearing a constitutive deletion of PTN. PTN-/- mice have significantly decreased phenotypic HSC content and competitive repopulating transplantation assays confirmed a 7-fold reduction in long-term HSCs.
Institutions: Duke University, University of California San Diego
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2002878660