Work

The T Cell Cytolytic Molecules Fas Ligand And Trail, The Trafficking Molecules CCR9, β7 Integrin And PSGL1, And The Immune Modulating Molecules OX40 And Ceacam1 Are Required For Thymic Graft-Versus-Host Disease

Year: 2009

Type: article

Abstract: Thymic graft-versus-host-disease (tGVHD) contributes to impaired T cell reconstitution after allogeneic bone marrow transplantation, but its pathophysiology has not been well defined. We assessed thymic output (RAG2+ splenic recent thymic emigrants) as well as the thymic cellularity (esp. CD4+CD8+ cells) and found that these were inversely related to numbers of mature donor T cells in the allograft. Bcl-2 expression in donor BM-derived thymocytes was decreased in recipients with GVHD vs. those without GVHD, which suggests that survival of thymocytes is decreased during tGVHD.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.379