Work

Synthesis of Functionalized Cyclohexenone Core of Welwitindolinones via Rhodium-Catalyzed [5 + 1] Cycloaddition

Year: 2012

Type: article

Abstract: The cyclohexenone core of welwitindolinones was synthesized by a Rh(I)-catalyzed [5 + 1]-cycloaddition of an allenylcyclopropane with CO. A pentasubstituted cyclopropane was prepared successfully by a Rh(II)-catalyzed intramolecular cyclopropanation of alkenes with chlorodiazoacetates.

Source: Organic Letters

DOI: 10.1021/ol301614v

Authors: Min Zhang, Weiping Tang

Institution: University of Wisconsin–Madison

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Amgen, National Institute of General Medical Sciences

Award: Development of Cyclopropyl Metal Carbene Based Methods for Organic Synthesis