Work

Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins

Year: 2008

Type: article

Abstract: p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Source: Current Molecular Medicine

DOI: 10.2174/156652408786733748

Authors: Jin Zhang, Xinbin Chen

Institution: University of California, Davis

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute