Influence of Previous Moderate Training on the Elevated Serum Levels of Growth Factors and Inflammatory Mediators in Rats Exposed to Acute Exhausting Physical Exercise
Year: 2014
Type: article
Abstract: Appropriate physical exercise improves both mental and physical health. However, strenuous exercise can cause muscle damage and inflammation. The mechanism of muscle adaptation to physical exercise is in some way unclear. The aim of the present study was to evaluate the influence of previous moderate training on the generation of growth factors and inflammatory cytokines following an acute bout of exhausting physical exercise. Forty eight male Wistar albino rats were used in the present study. Rats were randomly assigned (24/group) to untrained (UT), and trained (T, subjected to 6 week swimming training) groups. Each group was equally subdivided into pre- and post-exercise groups. Blood samples were collected either immediately before or after acute exhausting swimming exercise session (60 minutes continuous swimming). Strenuous exercise induced a significant increase (P < 0.05) in serum levels of transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α) in (UT) and (T) rats when compared to the corresponding baseline values. Exercise-induced increase in the circulating levels of growth factors and inflammatory cytokines was significantly (P < 0.05) lower in the (T) group when compared to the (UT) group. We concluded that prior moderate exercise training protects against the deleterious effects of acute strenuous physical exercise by influencing exercise-induced rise in the serum growth factors and inflammatory cytokines.
Authors: Yahya M. Naguib, Rania Azmy
Institution: Menoufia University
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W200338527