Work

Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection

Year: 2003

Type: article

Abstract: We present a dual-axes confocal microscope that employs postobjective scanning and low-coherence heterodyne detection to collect vertical cross-sectional images from biological tissue with high axial resolution, reduced noise from scattered light, deep tissue penetration, and a large dynamic range. This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy.

Source: Optics Letters

DOI: 10.1364/ol.28.001915

Authors: Thomas D. Wang, Christopher H. Contag, Michael J. Mandella, NingY. Chan, Gordon S. Kino

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G2667828762, G2848884011, Spatiotemporal Analysis of Neoplasia in Animal Models, Training Grant in Academic Gastroenterology