The Challenge of Using Gene- or Cell-Based Therapies to Treat Lung Disease
Year: 2012
Type: editorial
Abstract: As the organ of gas exchange, the human lung is designed to bring inspired air and venous blood into close approximation, allowing oxygen to be transferred to red blood cells coursing through the alveolar walls. In exchange, carbon dioxide, the waste gas of metabolism, is eliminated from the body. To accomplish this, the human lung has evolved as a complex structure with a complicated biology that is as yet only partially understood. This complexity, while a marvel from a biological viewpoint, is a challenge for the gene and cellular therapists who have directed their investigations to use gene therapy to cure lung disease and stem/progenitor cell therapy to reconstruct damaged or lost lung.
Source: Molecular Therapy
DOI: 10.1038/mt.2012.91
Author: Ronald G Crystal
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2003475460