Work

pH‐Responsive Theranostic Polymer‐Caged Nanobins: Enhanced Cytotoxicity and T 1 MRI Contrast by Her2 Targeting

Year: 2013

Type: article

Abstract: A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and GdIII-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

Source: Particle & Particle Systems Characterization

DOI: 10.1002/ppsc.201300158

Authors: Bong Jin Hong, Elden P. Swindell, Keith W. MacRenaris, Patrick L. Hankins, Anthony J. Chipre, Daniel J. Mastarone, Richard W. Ahn, Thomas J. Meade, Thomas V. O'Halloran, SonBinh T. Nguyen

Institution: Northwestern University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Northwestern University, National Institutes of Health, Robert H. Lurie Comprehensive Cancer Center, National Cancer Institute

Awards: Nanomaterials for Cancer Diagnostics and Therapeutics, Tumor Targeted Nanobins for the Treatment of Metastatic Breast and Ovarian Cancer, The Robert H. Lurie Comprehensive Cancer Center

OpenAlex ID: W2003518220

FWCI: 0.636

Cites: 42

Cited by: 16

Related to: 10