Work

Fluctuation-Preserving Coarse Graining for Biochemical Systems

Year: 2012
Type: article
Abstract: Finite stochastic Markov models play a major role in modeling biological systems. Such models are a coarse-grained description of the underlying microscopic dynamics and can be considered mesoscopic. The level of coarse-graining is to a certain extent arbitrary since it depends on the resolution of accommodating measurements. Here we present a systematic way to simplify such stochastic descriptions which preserves both the meso-micro and the meso-macro connections. The former is achieved by demanding locality, the latter by considering cycles on the network of states. Our method preserves fluctuations of observables much better than naïve approaches.
Language: English
Open Access status: green
OpenAlex ID: W2004035581
FWCI: 3.356
Cites: 22
Cited by: 42
Related to: 10