Work

Studies on the Cytotoxicity of Asterriquinone Derivatives.

Year: 1998

Type: article

Abstract: The antitumor agent, asterriquinone (ARQ) is a known metabolite isolated from the mycelium of Aspergillus terreus IFO 61231).YAMAMOTO et al. reported that ARQ analogues having a 2, 5-dimethoxy-p-benzoquinone moiety (ARQ dimethyl ether: ARQDMe)2,3) and the 2, 5-diamino-p-benzoquinone moiety (diamino ARQ: ARQDA)4) did not show any Cytotoxicity.As reported in our previous communication5), a new metabolite, asterridinone, which has a furo [3, 2-b] furan moiety instead of the p-benzoquinone moiety of ARQ, did not show cytotoxic activity towards P388 mouse leukemia cells, while isoasterriquinone and neoasterriquinone

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.51.235

Authors: AKIRA KAJI, TOMOKI IWATA, NORIKI KIRIYAMA, MASAAKI NOMURA, KEN-ICHI MIYAMOTO

Institutions: Hokuriku University, Kanazawa University

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Institute for Fermentation, Osaka, Bijzonder Onderzoeksfonds UGent