Work

Oleanolic Acid, a Bioactive Component of the Leaves of Ocimum Gratissimum (Lamiaceae)

Year: 1997

Type: article

Abstract: Bioactivity-guided fractionation of the leaves of Ocimum gratissimum L. (Lamiaceae), using the brine shrimp lethality test, led to the isolation of oleanolic acid. Oleanolic acid showed bioactivity against a panel of six human solid tumor cell lines, the nematode Caenorhabditis elegans and yellow fever mosquito larvae Aedes aegypti. Details of the isolation and bioactivities are described.

Source: Pharmaceutical Biology

DOI: 10.1076/phbi.35.2.134.13290

Authors: C.J. Njoku, Lu Zeng, I.U. Asuzu, N.H. Oberlies, J.L. McLaughlin

Institutions: University of Nigeria, Purdue University West Lafayette

Language: Spanish

Topic: Natural product bioactivities and synthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Purdue University, National Institutes of Health, National Cancer Institute, National Center for Research Resources