Work

Genetic programs controlling cortical interneuron fate

Year: 2014

Type: review

Abstract: The origins of cortical interneurons in rodents have been localized to the embryonic subcortical telencephalon where distinct neuroepithelial precursors generate defined interneuron subsets. A swathe of research activity aimed at identifying molecular determinants of subtype identity has uncovered a number of transcription factors that function at different stages of interneuron development. Pathways that lead to the acquisition of mature interneuron traits are therefore beginning to emerge. As genetic programs are influenced by external factors the search continues not only into genetic determinants but also extrinsic influences and the interplay between the two in cell fate specification.

Source: Current Opinion in Neurobiology

DOI: 10.1016/j.conb.2013.12.012

Authors: Nicoletta Kessaris, Lorenza Magno, Anna Noren Rubin, Marcio Guiomar Oliveira

Institution: University College London

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,211

Funders: Wellcome Trust, Agence Nationale de la Recherche, Medical Research Council, FP7 Ideas: European Research Council