Europium(III) DOTA-tetraamide Complexes as Redox-Active MRI Sensors
Year: 2012
Type: article
Abstract: PARACEST redox sensors containing the NAD(+)/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu(3+) complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.
DOI: 10.1021/ja211601k
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: PARACEST AGENTS FOR MOLECULAR IMAGING OF CANCER BY MRI, National Center for In Vivo Metabolism, Southwestern NMR Center for in Vivo Metabolism, G3455779667, G4094891941, G4214418682, G4812792742, G630325248, Evaluation of Iodorotenone, A SPECT Perfusion Tracer, PARACEST Agents: Optimization for Human MR Imaging, G828409569, UT Southwestern Medical Center Simmons Comprehensive Cancer Center
OpenAlex ID: W2004430934