Work

Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis

Year: 1995

Type: article

Abstract: Peroxynitrite stimulated the synthesis of cyclic GMP by rat aortic smooth muscle in a time- and dose-dependent manner. Peak formation of cyclic GMP occurred at 1 min with 100 microM peroxynitrite and was inhibited by oxyhemoglobin. Peroxynitrite was less potent than nitric oxide in stimulating cyclic GMP synthesis. Peroxynitrite also enhanced endothelial-dependent cyclic GMP synthesis, via generation of a long-lived substance, which was prevented by inhibition of glutathione synthesis. These data show that peroxynitrite stimulates cyclic GMP synthesis, inferring production of low yields of nitric oxide or associated derivatives. Additionally, vascular exposure to peroxynitrite potentiates endothelial-dependent activation of guanylate cyclase.

Source: FEBS Letters

DOI: 10.1016/0014-5793(95)00413-4

Authors: M.M. Tarpey, J.S. Beckman, H. Ischiropoulos, J.Z. Gore, T.A. Brock

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute