Work

Intestinal IgA production and its role in host‐microbe interaction

Year: 2014

Type: review

Abstract: Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo-responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non-inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host-microbe interaction.

Source: Immunological Reviews

DOI: 10.1111/imr.12189

Authors: Cindy Gutzeit, Giuliana Magri, Andrea Cerutti

Institutions: Icahn School of Medicine at Mount Sinai, Barcelona Biomedical Research Park, Hospital del Mar Research Institute, Institució Catalana de Recerca i Estudis Avançats

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases