Work

PASADENA Hyperpolarized 13C Phospholactate

Year: 2012

Type: article

Abstract: We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja210639c

Authors: Roman V. Shchepin, Aaron M. Coffey, Kevin W. Waddell, Eduard Y. Chekmenev

Institution: Vanderbilt University

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Institutes of Health, National Cancer Institute