Year: 1999
Type: article
Study design: Case Report
Abstract: G ene transfer of phVEGF-2, an endothelial cell mitogen previously shown to promote angiogenesis in preclinical animal studies, is intended to promote collateral vessel development to the ischemic lateral LV wall.The strategy of gene delivery used in this case is designed to exploit the fact that muscle, particularly myocardium, yields relatively higher levels of gene expression than other tissue types; electrome-chanical mapping was used in this case to guide injection to sites of myocardial ischemia, because ischemic muscle yields even higher levels of gene expression.The patient was an 82-year-old man with coronary heart disease, including an old anteroseptal myocardial infarction (MI), previous coronary artery bypass surgery, and chronic angina refractory to medical therapy.
Source: Circulation
Institutions: Tufts University, St. Elizabeth's Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2004673654