Work

TNFα -238A Allele Identifies Patients Who Develop Both Acute and Chronic GVHD After Matched Unrelated Donor Transplant in Children: A Pediatric Blood and Marrow Transplant Consortium Study

Year: 2012

Type: article

Abstract: The inflammatory cytokine tumor necrosis factor-α (TNFα) plays a central role in the pathogenesis of acute GVHD, but its role in chronic GVHD is less clearly defined. We recently described an association between the recipient TNFα gene polymorphisms and the severity of acute GVHD in pediatric unrelated donor BMT (Goyal et al, Biol Blood Marrow Transplant, 2010). We now report the correlative analyses between the recipient and donor TNFα promoter region single nucleotide gene polymorphisms (SNP) and the risk of acute and chronic GVHD in this cohort.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.438