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Functional Role of Type I and Type II Interferons in Antiviral Defense

Year: 1994

Type: article

Abstract: Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

Source: Science

DOI: 10.1126/science.8009221

Authors: Ulrike Müller, Ulrich Steinhoff, Luiz F. L. Reis, Silvio Hemmi, Jovan Pavlovic, Rolf M. Zinkernagel, Michel Aguet

Institution: University of Zurich

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2004829503

FWCI: 18.35

Cites: 33

Cited by: 2,470

Related to: 10