Year: 2013
Type: review
Abstract: The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progression. Animal models contribute to increase the knowledge on the pathophysiology of neurodegenerative diseases. These models reproduce different aspects of a given disease, as well as the histopathological lesions and its main symptoms. The purpose of this review is to present the main animal models for AD, PD, and Huntington's disease.
Source: Brazilian Journal of Psychiatry
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: PARTICIPAÇÃO DO SISTEMA ENDOCANABINOIDE E DE VIAS INTRACELULARES RELACIONADAS EM RESPOSTAS COMPORTAMENTAIS E MOLECULARES À NEUROINFLAMAÇÃO., G2724807733, CARACTERIZAÇÃO DO RECEPTOR METABOTRÓPICO DE GLUTAMATO 5 COMO ALVO TERAPÊUTICO NA DOENÇA DE HUNTINGTON, ESTUDO DE ASPECTOS IMUNES E INFLAMATÓRIOS NA DOENÇA DE PARKINSON, G647434686
OpenAlex ID: W2004958773