Work

A requirement for ER-derived COPII vesicles in phagophore initiation

Year: 2014

Type: article

Abstract: A major unanswered question in the field of autophagy is how the double-membrane phagophore is formed. As this membrane expands, it engulfs proteins and organelles that are destined for degradation and then seals to form an autophagosome. A growing consensus in the field is that a subdomain of the ER initiates formation of the phagophore. We show that ER-derived COPII-coated vesicles, which bud from a specialized domain of the ER called the ER exit site (ERES), are a source of this membrane. This finding will now pave the way for a biochemical description of the early steps of phagophore initiation.

Source: Autophagy

DOI: 10.4161/auto.28103

Authors: Juan Wang, Dongyan Tan, Yiying Cai, Karin M Reinisch, Thomas Walz, Susan Ferro-Novick

Institutions: Howard Hughes Medical Institute, University of California San Diego, Harvard University, Yale University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of General Medical Sciences

Awards: Lipid transporters and lipid homeostasis at membrane contact sites, G2089823532, G7415745935