Work

Dexamethasone and Cyclosporin A Suppress Mast Cell-Leukocyte Cytokine Cascades by Multiple Mechanisms

Year: 2009

Type: article

Abstract: Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: suppression of the IgE-dependent increase in tumor necrosis factor (TNF)-alpha mRNA by mast cells, inhibition of the IgE-dependent production of TNF-alpha protein by mast cells, and diminution of the responsiveness of target cells to TNF-alpha. Our findings in mice raise the possibility that similar actions of these agents in humans may account for some of the clinical efficacy of corticosteroids and cyclosporin A in allergic diseases.

Source: International Archives of Allergy and Immunology

DOI: 10.1159/000237015

Authors: Barry K. Wershil, Glenn T. Furuta, Jackie A. Lavigne, Anjona Roy Choudhury, Zhen S. Wang, Stephen J. Galli

Institutions: Boston Children's Hospital, Harvard University, Massachusetts General Hospital

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze