Work

Adenovirus Late Gene Expression Does Not Require a Rev-Like Nuclear RNA Export Pathway

Year: 2000

Type: article

Abstract: Adenovirus late mRNA export is facilitated by viral early proteins of 55 and 34 kDa. The 34-kDa protein contains a leucine-rich nuclear export signal (NES) similar to that of the human immunodeficiency virus Rev protein. It was proposed that the 34-kDa protein might facilitate the export of adenovirus late mRNA through a Rev-like NES-mediated export pathway. We have tested the role of NES-mediated RNA export during adenovirus infection, and we find that it is not essential for the expression of adenovirus late genes.

Source: Journal of Virology

DOI: 10.1128/jvi.74.14.6684-6688.2000

Authors: Claudia Rabino, Anders Aspegren, Kara Corbin-Lickfett, Eileen Bridge

Institutions: Uppsala University, Miami University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: American-Scandinavian Foundation, US-UK Fulbright Commission, Medical Research Council, National Cancer Institute

Award: G4105686119