A candidate precursor to serous carcinoma that originates in the distal fallopian tube (J Pathol 2007; 211: 26–35)
Year: 2007
Type: article
Study design: Observational Study
Abstract: In this recent paper, the frequency of p53 signatures in the fallopian tubes of BRCA+ women was recorded as 24% (10/24), in contrast to women with other disorders, which was 33% (19/58). We have since discovered that a proportion of the cases originally classified as BRCA+ in our high-risk population had not been documented genetically as having a BRCA mutation. To address this error, we reviewed p53 immunostains from 605 tissue blocks of 75 consecutive prophylactic salpingectomies from women with documented BRCA mutations at our institution. This cohort included the cases in our report; 37% (28/75) contained p53 signatures. This does not alter the conclusion that p53 signatures have a similar frequency in women with and without a documented BRCA mutation. However, it provides a more accurate estimate of the latter and reiterates the hypothesis that the initial phase of serous carcinogenesis in the fallopian tube is not BRCA-dependent.
Source: The Journal of Pathology
DOI: 10.1002/path.2212
Authors: Y Lee, A Miron, R Drapkin, MR Nucci, F Medeiros, A Saleemuddin, J Garber, C Birch, H Mou, RW Gordon, DW Cramer, FD McKeon, CP Crum
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2005278622