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Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles

Year: 2009

Type: article

Abstract: An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja900591t

Authors: Sarit S. Agasti, Apiwat Chompoosor, Chang-Cheng You, Partha Ghosh, Chae Kyu Kim, Vincent M. Rotello

Institution: University of Massachusetts Amherst

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences