Work

Biological characterizations of [Gd@C82(OH)22]nnanoparticles as fullerene derivatives for cancer therapy

Year: 2012

Type: review

Abstract: Malignant tumor disease is one of the leading causes of human death in many countries. Currently, chemotherapy is considered highly efficient for cancer treatment. However, the clinical application of conventional chemotherapeutic agents is limited because of their high toxicity. With the development of nanotechnology, engineered nanomaterials have been widely and increasingly used in biomedical fields such as biomedicine. Thus, the use of engineered nanomaterials has become a promising approach to cancer treatment. Many newly fabricated nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties, implying their enormous potential as biomedical candidates. [Gd@C(82)(OH)(22)](n) is a new type of metallofullerenol nanoparticle with high anti-tumor activity but low toxicity. In this article, the properties and biological effects of [Gd@C(82)(OH)(22)](n) are summarized, and their possible mechanisms are analyzed.

Source: Integrative Biology

DOI: 10.1039/c2ib20145c

Authors: Jie Meng, Xingjie Liang, Xiaoyuan Chen, Yuliang Zhao

Institutions: Chinese Academy of Sciences, National Center for Nanoscience and Technology, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Institute of High Energy Physics

Language: English

Topic: Fullerene Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering