Work

DNA pooling as a tool for large‐scale association studies in complex traits

Year: 2004

Type: article

Abstract: Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.

Source: Annals of Medicine

DOI: 10.1080/07853890310021724

Authors: Nadine Norton, Nigel Williams, Michael O'Donovan, Michael Owen

Institutions: Cardiff University, University of Wales

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2005326944

FWCI: 4.641

Cites: 32

Cited by: 77

Related to: 10