Work

Role of Phospholipids in the Multiple Forms of Mammalian Elongation Factor 1

Year: 1974

Type: article

Abstract: Evidence is presented that high-molecular-weight aggregates of elongation factor 1 from calf brain and liver contain phospholipids. Sucrose gradient analysis has shown that these high-molecular-weight species can be converted to a low-molecular-weight form after incubation with different phospholipase preparations. In addition, a partially purified elongation factor 1 from rabbit reticulocytes is also converted to a low-molecular-weight species by phospholipase treatment. These data indicate that phospholipids are involved in maintaining the integrity of the high-molecular-weight species and support the view that this species is an aggregate of the low-molecular-weight elongation factor 1.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.71.6.2179

Authors: Andrzej B. Legocki, Betty Redfield, Chen K. Liu, Herbert Weissbach

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2005330467

FWCI: 1.965

Cites: 14

Cited by: 17

Related to: 10