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Fluconazole resistance in Candida glabrata

Year: 1993

Type: article

Abstract: We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 microM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.37.9.1962

Authors: C A Hitchcock, G W Pye, P F Troke, E M Johnson, D W Warnock

Institution: Pfizer (United Kingdom)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2005360569

FWCI: 18.84

Cites: 28

Cited by: 244

Related to: 10