Work

Postinfluenza Bacterial Pneumonia: Host Defenses Gone Awry

Year: 2010

Type: review

Abstract: Influenza is a common respiratory pathogen causing both seasonal and pandemic disease. Influenza infection predisposes the host to secondary bacterial infection of the respiratory tract, which is a major cause of both morbidity and mortality in flu-related disease. In this review, we will discuss innate and adaptive antiviral responses during influenza infection, and review how these responses modulate protective immunity against secondary bacterial pathogens of the lung. Specific emphasis will be placed on implications of bacterial superinfection and mechanisms involved.

Source: Journal of Interferon & Cytokine Research

DOI: 10.1089/jir.2010.0049

Authors: Megan N. Ballinger, Theodore J. Standiford

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute