Work

Solid-Phase Synthesis of Callipeltin D. Stereochemical Confirmation of the Unnatural Amino Acid AGDHE

Year: 2005

Type: article

Abstract: [structure: see text] The lipopeptide callipeltin D (1) was synthesized using an Fmoc-based solid-phase strategy in seven steps and 35% overall yield. The 1H NMR of synthetic 1 correlated closely with that of the natural product, confirming the configurational assignment of the novel amino acid constituent (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxyheptanoic acid.

Source: Organic Letters

DOI: 10.1021/ol052438f

Authors: David C. Cranfill, Ángel I. Morales-Ramos, Mark A. Lipton

Institution: Purdue University West Lafayette

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Studies of Antitumor,Anti HIV Cyclic Depsipeptides