Work

Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)

Year: 2012

Type: article

Abstract: The PHLPP (pleckstrin homology domain and leucine-rich repeat protein phosphatase) family of novel Ser/Thr phosphatases serve as important regulators of cell survival and apoptosis. 1 , 2 These proposed tumor-suppressors lead to inactivation of Akt, degradation of PKC and negatively regulate ERK1/2 activation. 2 , 3 , 4 Furthermore, reductions in PHLPP1 and/or PHLPP2 expression have been detected in several cancers and linked to cancer progression. 4 , 5 , 6 , 7

Source: Leukemia

DOI: 10.1038/leu.2012.6

Authors: M O'Hayre, M Niederst, J F Fecteau, V M Nguyen, T J Kipps, D Messmer, A C Newton, T M Handel

Institutions: University of California San Diego, Moores Cancer Center

Language: English

Topic: Chronic Lymphocytic Leukemia Research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190

Funders: California Breast Cancer Research Program, National Institutes of Health, U.S. Public Health Service, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Structure, Function and Regulation of Protein Kinase C, Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase, Structure-Function Studies & Molecular Interactions of Chemokines, Graduate Training in Cellular and Molecular Pharmacology, G6963084959, Structure, Function and Regulation of Protein Kinase C, Chronic Lymphocytic Leukemia Research Consortium, G9000008283, G944802235

OpenAlex ID: W2005438787

FWCI: 0.722

Cites: 14

Cited by: 18

Related to: 10